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Target
Transporter
Ligand
BDBM50324234
Substrate
n/a
Meas. Tech.
ChEMBL_649988 (CHEMBL1219686)
Ki
2610±n/a nM
Citation
 Zhang, P; Cyriac, G; Kopajtic, T; Zhao, Y; Javitch, JA; Katz, JL; Newman, AH Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. J Med Chem 53:6112-21 (2010) [PubMed]  Article 
Target
Name:
Transporter
Synonyms:
NE transporter | NET | Norepinephrine transporter(NET)
Type:
Multi-pass membrane protein
Mol. Mass.:
69236.90
Organism:
Rattus norvegicus (rat)
Description:
Q63380
Residue:
617
Sequence:
MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKERNGVQCLLASQDGDAQPRETWGKEIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHLVAQRDVRQFQLRHWLAI
  
Inhibitor
Name:
BDBM50324234
Synonyms:
3-(1-(4-Fluorophenyl)-5-(3'-methoxyphenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine | CHEMBL1214689
Type:
Small organic molecule
Emp. Form.:
C26H28FNO2
Mol. Mass.:
405.5044
SMILES:
COc1cccc(c1)-c1ccc2c(COC2(CCCN(C)C)c2ccc(F)cc2)c1
Structure:
Search PDB for entries with ligand similarity: