Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM50128581
Substrate
n/a
Meas. Tech.
ChEMBL_650749 (CHEMBL1227509)
IC50
200000±n/a nM
Citation
 Long, JZ; Li, W; Booker, L; Burston, JJ; Kinsey, SG; Schlosburg, JE; Pavón, FJ; Serrano, AM; Selley, DE; Parsons, LH; Lichtman, AH; Cravatt, BF Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol 5:37-44 (2008) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
MAGL | MGLL_RAT | Mgl2 | Mgll | Monoacylglycerol lipase | Monoglyceride lipase | Monoglyceride lipase (MGL)
Type:
Enzyme
Mol. Mass.:
33505.38
Organism:
Rattus norvegicus (Rat)
Description:
Q8R431
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLGHSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRIDSSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGARCLP
  
Inhibitor
Name:
BDBM50128581
Synonyms:
Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHEMBL77767 | URB602 | biphenyl-3-ylcarbamic acid cyclohexyl ester | cyclohexyl biphenyl-3-ylcarbamate
Type:
Small organic molecule
Emp. Form.:
C19H21NO2
Mol. Mass.:
295.3755
SMILES:
O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1
Structure:
Search PDB for entries with ligand similarity: