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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50325290
Substrate
n/a
Meas. Tech.
ChEMBL_651967 (CHEMBL1227640)
IC50
8.8±n/a nM
Citation
 Hong, PC; Chen, LJ; Lai, TY; Yang, HY; Chiang, SJ; Lu, YY; Tsai, PK; Hsu, HY; Wei, WY; Liao, CB Synthesis of selenophene derivatives as novel CHK1 inhibitors. Bioorg Med Chem Lett 20:5065-8 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50325290
Synonyms:
5-((6-(4-hydroxy-3-methoxyphenyl)-2-oxoindolin-3-ylidene)methyl)-N-(2-morpholinoethyl)selenophene-2-carboxamide | CHEMBL1223117
Type:
Small organic molecule
Emp. Form.:
C27H27N3O5Se
Mol. Mass.:
552.48
SMILES:
COc1cc(ccc1O)-c1ccc2\C(=C\c3ccc([se]3)C(=O)NCCN3CCOCC3)C(=O)Nc2c1
Structure:
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