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Target
Transcription factor Jun
Ligand
BDBM50279429
Substrate
n/a
Meas. Tech.
ChEMBL_657293 (CHEMBL1249120)
IC50
3000±n/a nM
Citation
 Giri, RS; Thaker, HM; Giordano, T; Chen, B; Nuthalapaty, S; Vasu, KK; Sudarsanam, V Synthesis and evaluation of quinazolinone derivatives as inhibitors of NF-kappaB, AP-1 mediated transcription and eIF-4E mediated translational activation: inhibitors of multi-pathways involve in cancer. Eur J Med Chem 45:3558-63 (2010) [PubMed]  Article 
Target
Name:
Transcription factor Jun
Synonyms:
AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:
n/a
Mol. Mass.:
35683.24
Organism:
Homo sapiens (Human)
Description:
P05412
Residue:
331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
  
Inhibitor
Name:
BDBM50279429
Synonyms:
3-(4-Chloro-phenyl)-2-(4-methyl-2-methylamino-thiazol-5-yl)-3H-quinazolin-4-one | CHEMBL487336
Type:
Small organic molecule
Emp. Form.:
C19H15ClN4OS
Mol. Mass.:
382.867
SMILES:
CNc1nc(C)c(s1)-c1nc2ccccc2c(=O)n1-c1ccc(Cl)cc1
Structure:
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