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Target
Cytochrome P450 1A2
Ligand
BDBM21360
Substrate
n/a
Meas. Tech.
ChEMBL_665567 (CHEMBL1261451)
IC50
500±n/a nM
Citation
 Micheli, F; Arista, L; Bertani, B; Braggio, S; Capelli, AM; Cremonesi, S; Di-Fabio, R; Gelardi, G; Gentile, G; Marchioro, C; Pasquarello, A; Provera, S; Tedesco, G; Tarsi, L; Terreni, S; Worby, A; Heidbreder, C Exploration of the amine terminus in a novel series of 1,2,4-triazolo-3-yl-azabicyclo[3.1.0]hexanes as selective dopamine D3 receptor antagonists. J Med Chem 53:7129-39 (2010) [PubMed]  Article 
Target
Name:
Cytochrome P450 1A2
Synonyms:
CP1A2_HUMAN | CYP1A2 | CYPIA2 | Cholesterol 25-hydroxylase | Cytochrome P(3)450 | Cytochrome P450 1A | Cytochrome P450 1A2 (CYP1A2) | Cytochrome P450 4 | Cytochrome P450-P3
Type:
Enzyme
Mol. Mass.:
58423.38
Organism:
Homo sapiens (Human)
Description:
P05177
Residue:
516
Sequence:
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
  
Inhibitor
Name:
BDBM21360
Synonyms:
7-ethoxy-3H-phenoxazin-3-one | 7-ethoxyresorufin | Ethoxyresorufin | US9216974, Ethoxy-resorufin
Type:
Small organic molecule
Emp. Form.:
C14H11NO3
Mol. Mass.:
241.242
SMILES:
CCOc1ccc2nc3ccc(=O)cc3oc2c1
Structure:
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