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Target
PH domain leucine-rich repeat-containing protein phosphatase 2
Ligand
BDBM50328829
Substrate
n/a
Meas. Tech.
ChEMBL_673824 (CHEMBL1275001)
IC50
20000±n/a nM
Citation
 Sierecki, E; Sinko, W; McCammon, JA; Newton, AC Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening. J Med Chem 53:6899-911 (2010) [PubMed]  Article 
Target
Name:
PH domain leucine-rich repeat-containing protein phosphatase 2
Synonyms:
KIAA0931 | PH domain leucine-rich repeat-containing protein phosphatase-like | PHLP2_HUMAN | PHLPP-like | PHLPP2 | PHLPPL
Type:
PROTEIN
Mol. Mass.:
146727.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_673824
Residue:
1323
Sequence:
MKRNGSRNCLNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTTTSSSSSSSSSSSDLHLVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPTERPLQIVYDYLSRLGFDDPVRIQEEATNPDLGCMIRFYGEKPCHMDRLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKRRQYSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPLPTTDSTVTSTFWSHGLAEMAGQRNKLCVSALAMDSFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQQSTNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPASSFSLTVANVGTCQAVLCRGGKPVPLSKVFSLEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFASTTTIKDAPKPATPSSSSGIASEFSSEMSTSEVSSEVGSTASDEHNAGGLDTALLPRPERRCSLHPTPTSGLFQRQPSSATFSSNQSDNGLDSDDDQPVEGVITNGSKVEVEVDIHCCRGRDLENSPPLIESSPTLCSEEHARGSCFGIRRQNSVNSGMLLPMSKDRMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEVPKRKTGYFAAPTQMEPEDQFVVPHDLEEEVKEQMKQHQDSRLEPEPHEEDRTEPPEEFDTAL
  
Inhibitor
Name:
BDBM50328829
Synonyms:
5-(4'-((2,4-diamino-5-((4-sulfophenyl)diazenyl)phenyl)diazenyl)biphenyl-4-yl)diazenyl)-2-hydroxybenzoic acid | CHEMBL1269666 | NSC-51532
Type:
Small organic molecule
Emp. Form.:
C31H24N8O6S
Mol. Mass.:
636.637
SMILES:
Nc1cc(N)c(cc1N=Nc1ccc(cc1)-c1ccc(cc1)N=Nc1ccc(O)c(c1)C(O)=O)N=Nc1ccc(cc1)S(O)(=O)=O |w:23.26,9.10,34.37|
Structure:
Search PDB for entries with ligand similarity: