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Target
PH domain leucine-rich repeat-containing protein phosphatase 2
Ligand
BDBM50328834
Substrate
n/a
Meas. Tech.
ChEMBL_673824 (CHEMBL1275001)
IC50
39000±n/a nM
Citation
 Sierecki, E; Sinko, W; McCammon, JA; Newton, AC Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening. J Med Chem 53:6899-911 (2010) [PubMed]  Article 
Target
Name:
PH domain leucine-rich repeat-containing protein phosphatase 2
Synonyms:
KIAA0931 | PH domain leucine-rich repeat-containing protein phosphatase-like | PHLP2_HUMAN | PHLPP-like | PHLPP2 | PHLPPL
Type:
PROTEIN
Mol. Mass.:
146727.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_673824
Residue:
1323
Sequence:
MKRNGSRNCLNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTTTSSSSSSSSSSSDLHLVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPTERPLQIVYDYLSRLGFDDPVRIQEEATNPDLGCMIRFYGEKPCHMDRLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKRRQYSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPLPTTDSTVTSTFWSHGLAEMAGQRNKLCVSALAMDSFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQQSTNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPASSFSLTVANVGTCQAVLCRGGKPVPLSKVFSLEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFASTTTIKDAPKPATPSSSSGIASEFSSEMSTSEVSSEVGSTASDEHNAGGLDTALLPRPERRCSLHPTPTSGLFQRQPSSATFSSNQSDNGLDSDDDQPVEGVITNGSKVEVEVDIHCCRGRDLENSPPLIESSPTLCSEEHARGSCFGIRRQNSVNSGMLLPMSKDRMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEVPKRKTGYFAAPTQMEPEDQFVVPHDLEEEVKEQMKQHQDSRLEPEPHEEDRTEPPEEFDTAL
  
Inhibitor
Name:
BDBM50328834
Synonyms:
3-((4'-((6-amino-1-hydroxy-3-sulfonaphthalen-2-yl)diazenyl)-3,3'-dimethoxybiphenyl-4-yl)diazenyl)-4-hydroxynaphthalene-1-sulfonic acid | CHEMBL1269664 | NSC-47754
Type:
Small organic molecule
Emp. Form.:
C34H27N5O10S2
Mol. Mass.:
729.736
SMILES:
COc1cc(ccc1N=Nc1cc(c2ccccc2c1O)S(O)(=O)=O)-c1ccc(N=Nc2c(O)c3ccc(N)cc3cc2S(O)(=O)=O)c(OC)c1 |w:30.33,8.8|
Structure:
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