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Target
Stearoyl-CoA desaturase
Ligand
BDBM50329975
Substrate
n/a
Meas. Tech.
ChEMBL_676021 (CHEMBL1272959)
IC50
4246±n/a nM
Citation
 Powell, DA; Ramtohul, Y; Lebrun, ME; Oballa, R; Bhat, S; Falgueyret, JP; Guiral, S; Huang, Z; Skorey, K; Tawa, P; Zhang, L 2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors. Bioorg Med Chem Lett 20:6366-9 (2010) [PubMed]  Article 
Target
Name:
Stearoyl-CoA desaturase
Synonyms:
Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1
Type:
Enzyme
Mol. Mass.:
41537.27
Organism:
Homo sapiens (Human)
Description:
O00767
Residue:
359
Sequence:
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
  
Inhibitor
Name:
BDBM50329975
Synonyms:
6-(methylsulfonyl)-2-(4-(pyridin-4-yl)phenyl)-1H-benzo[d]imidazole | CHEMBL1271876
Type:
Small organic molecule
Emp. Form.:
C19H15N3O2S
Mol. Mass.:
349.406
SMILES:
CS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccc(cc1)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: