Reaction Details Report a problem with these data
Target
Stearoyl-CoA desaturase
Ligand
BDBM50329964
Substrate
n/a
Meas. Tech.
ChEMBL_676021 (CHEMBL1272959)
IC50
74±n/a nM
Citation
 Powell, DA; Ramtohul, Y; Lebrun, ME; Oballa, R; Bhat, S; Falgueyret, JP; Guiral, S; Huang, Z; Skorey, K; Tawa, P; Zhang, L 2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors. Bioorg Med Chem Lett 20:6366-9 (2010) [PubMed]  Article 
Target
Name:
Stearoyl-CoA desaturase
Synonyms:
Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1
Type:
Enzyme
Mol. Mass.:
41537.27
Organism:
Homo sapiens (Human)
Description:
O00767
Residue:
359
Sequence:
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
  
Inhibitor
Name:
BDBM50329964
Synonyms:
2-(2'-fluorobiphenyl-4-yl)-1H-benzo[d]imidazole-6-sulfonamide | CHEMBL1272202
Type:
Small organic molecule
Emp. Form.:
C19H14FN3O2S
Mol. Mass.:
367.397
SMILES:
NS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccc(cc1)-c1ccccc1F
Structure:
Search PDB for entries with ligand similarity: