Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM50332961
Substrate
n/a
Meas. Tech.
ChEMBL_696202 (CHEMBL1639355)
IC50
0.46±n/a nM
Citation
 Mehta, PD; Sengar, NP; Pathak, AK 2-Azetidinone--a new profile of various pharmacological activities. Eur J Med Chem 45:5541-60 (2010) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM50332961
Synonyms:
(3S,4S)-3-Benzyl-4-(4-methylpiperazincarbonyl)phenoxy-1-[(R)-1-(phenylethyl)aminocarbonyl]azetidin-2-one | CHEMBL1631751
Type:
Small organic molecule
Emp. Form.:
C30H34N4O3
Mol. Mass.:
498.616
SMILES:
C[C@@H](NC(=O)N1[C@H](Oc2ccc(cc2)N2CCN(C)CC2)[C@H](Cc2ccccc2)C1=O)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: