Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50333790
Substrate
n/a
Meas. Tech.
ChEMBL_700973 (CHEMBL1648028)
IC50
>1660±n/a nM
Citation
 Mouchlis, VD; Magrioti, V; Barbayianni, E; Cermak, N; Oslund, RC; Mavromoustakos, TM; Gelb, MH; Kokotos, G Inhibition of secreted phospholipases A2 by 2-oxoamides based ona-amino acids: Synthesis, in vitro evaluation and molecular docking calculations. Bioorg Med Chem 19:735-43 (2011) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50333790
Synonyms:
(S)-4-Methyl-2-palmitamidopentanoic acid | CHEMBL1644551
Type:
Small organic molecule
Emp. Form.:
C22H43NO3
Mol. Mass.:
369.5817
SMILES:
CCCCCCCCCCCCCCCC(=O)N[C@@H](CC(C)C)C(O)=O |r|
Structure:
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