Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 3
Ligand
BDBM50335513
Substrate
n/a
Meas. Tech.
ChEMBL_702153 (CHEMBL1655490)
EC50
996±n/a nM
Citation
Cee, VJ; Frohn, M; Lanman, BA; Golden, J; Muller, K; Neira, S; Pickrell, A; Arnett, H; Buys, J; Gore, A; Fiorino, M; Horner, M; Itano, A; Lee, MR; McElvain, M; Middleton, S; Schrag, M; Rivenzon-Segal, D; Vargas, HM; Xu, H; Xu, Y; Zhang, X; Siu, J; Wong, M Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5 ACS Med Chem Lett 2:107-112 (2011) [PubMed] Article
More Info.:
Target
Name:
Sphingosine 1-phosphate receptor 3
Synonyms:
C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42278.13
Organism:
Homo sapiens (Human)
Description:
Q99500
Residue:
378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
Inhibitor
Name:
BDBM50335513
Synonyms:
1-((3-fluoro-4-(5-((R)-1-phenylethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)methyl)azetidine-3-carboxylic acid | CHEMBL1651859
Type:
Small organic molecule
Emp. Form.:
C25H22FN3O2S
Mol. Mass.:
447.524
SMILES:
C[C@H](c1ccccc1)c1ccc2nc(sc2n1)-c1ccc(CN2CC(C2)C(O)=O)cc1F |r|