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Target
Sterol O-acyltransferase 2
Ligand
BDBM50336545
Substrate
n/a
Meas. Tech.
ChEMBL_724421 (CHEMBL1678072)
IC50
2400±n/a nM
Citation
 White, PW; Llinàs-Brunet, M; Amad, M; Bethell, RC; Bolger, G; Cordingley, MG; Duan, J; Garneau, M; Lagacé, L; Thibeault, D; Kukolj, G Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease. Antimicrob Agents Chemother 54:4611-8 (2010) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 2
Synonyms:
Acat2 | Acyl coenzyme A:cholesterol acyltransferase 2 | SOAT2_RAT | Soat2 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
60517.03
Organism:
Rattus norvegicus
Description:
ChEMBL_724421
Residue:
524
Sequence:
MEPKAPQLRRRERQGEEQENGACGEGNTRTHRAPDLVQWTRHMEAVKTQCLEQAQRELAELMDRAIWEAVQAYPKQDRPLPSTASDSTRKTQELHPGKRKVFITRKSLLDELMGVQHFRTIYHMFIAGLCVLIISTLAIDFIDEGRLMLEFDLLLFSFGQLPLALMMWVPMFLSTLLLPYQTLRLWARPRSGGAWTLGASLGCVLLAAHAAVLCVLPVHVSVKHELPPASRCVLVFEQVRFLMKSYSFLRETVPGIFCVRGGKGICTPSFSSYLYFLFCPTLIYRETYPRTPSIRWNYVAKNFAQALGCLLYACFILGRLCVPVFANMSREPFSTRALLLSILHATGPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLWLLGRQGRGAAMLGVFLVSALVHEYIFCFVLGFFYPVMLILFLVVGGLLNFTMNDRHTGPAWNILMWTFLFLGQGIQVSLYCQEWYARRHCPLPQPTFWELVTPRSWSCHP
  
Inhibitor
Name:
BDBM50336545
Synonyms:
(1R,2S)-1-((2S,4R)-4-(8-bromo-2-(2-isobutyramidothiazol-4-yl)-7-methoxyquinolin-4-yloxy)-1-((S)-2-(cyclopentyloxycarbonylamino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylic acid | CHEMBL1241348 | N-[(cyclopentyloxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(8-bromo-7-methoxy-2-{2-[(2-methylpropanoyl)amino]-1,3-thiazol-4-yl}quinolin-4-yl)oxy]-N-[(1R,2S)-1-carboxy-2-ethenylcyclopropyl]-L-prolinamide
Type:
Small organic molecule
Emp. Form.:
C40H49BrN6O9S
Mol. Mass.:
869.821
SMILES:
COc1ccc2c(O[C@@H]3C[C@H](N(C3)C(=O)[C@@H](NC(=O)OC3CCCC3)C(C)(C)C)C(=O)N[C@@]3(C[C@H]3C=C)C(O)=O)cc(nc2c1Br)-c1csc(NC(=O)C(C)C)n1 |r|
Structure:
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