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Target
Prostaglandin E synthase
Ligand
BDBM50227631
Substrate
n/a
Meas. Tech.
ChEMBL_728760 (CHEMBL1686173)
IC50
1300±n/a nM
Citation
 Chiasson, JF; Boulet, L; Brideau, C; Chau, A; Claveau, D; Côté, B; Ethier, D; Giroux, A; Guay, J; Guiral, S; Mancini, J; Massé, F; Méthot, N; Riendeau, D; Roy, P; Rubin, J; Xu, D; Yu, H; Ducharme, Y; Friesen, RW Trisubstituted ureas as potent and selective mPGES-1 inhibitors. Bioorg Med Chem Lett 21:1488-92 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50227631
Synonyms:
2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile | CHEMBL412099
Type:
Small organic molecule
Emp. Form.:
C23H11ClN4
Mol. Mass.:
378.813
SMILES:
Clc1ccc2c3[nH]c(nc3c3ccccc3c2c1)-c1c(cccc1C#N)C#N
Structure:
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