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Target
Acyl-CoA desaturase 1
Ligand
BDBM50338530
Substrate
n/a
Meas. Tech.
ChEMBL_728487 (CHEMBL1685364)
IC50
2750±n/a nM
Citation
 Atkinson, KA; Beretta, EE; Brown, JA; Castrodad, M; Chen, Y; Cosgrove, JM; Du, P; Litchfield, J; Makowski, M; Martin, K; McLellan, TJ; Neagu, C; Perry, DA; Piotrowski, DW; Steppan, CM; Trilles, R N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors. Bioorg Med Chem Lett 21:1621-5 (2011) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1)
Type:
Enzyme
Mol. Mass.:
41485.97
Organism:
Rattus norvegicus (Rat)
Description:
P07308
Residue:
358
Sequence:
MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50338530
Synonyms:
CHEMBL1683585 | N-(2-acetamidoethyl)-1-(4-fluoro-3-(trifluoromethyl)benzyl)-1H-imidazole-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C16H16F4N4O2
Mol. Mass.:
372.3175
SMILES:
CC(=O)NCCNC(=O)c1cn(Cc2ccc(F)c(c2)C(F)(F)F)cn1
Structure:
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