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Target
Signal transducer and activator of transcription 3
Ligand
BDBM50338996
Substrate
n/a
Meas. Tech.
ChEMBL_729310 (CHEMBL1695665)
IC50
61000±n/a nM
Citation
 Masuda, Y; Sato, H; Takahashi, O; Yokotagawa, T; Furuya, T; Okawara, T; Otsuka, M; Ogo, N; Ashizawa, T; Oshita, C; Tai, S; Ishii, H; Akiyama, Y; Asai, A. Identification of a New Series of STAT3 Inhibitors by Virtual Screening. ACS Med Chem Lett 1:371-375 (2010) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3)
Type:
Protein
Mol. Mass.:
88064.31
Organism:
Homo sapiens (Human)
Description:
P40763
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
  
Inhibitor
Name:
BDBM50338996
Synonyms:
2-(4-Chlorophenyl)-N-(5-phenyl-1,3,4-oxadiazol-2-yl)-4-quinolinecarboxamide | CHEMBL1687967
Type:
Small organic molecule
Emp. Form.:
C24H15ClN4O2
Mol. Mass.:
426.855
SMILES:
Clc1ccc(cc1)-c1nnc(NC(=O)c2cc(nc3ccccc23)-c2ccccc2)o1
Structure:
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