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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50340461
Substrate
n/a
Meas. Tech.
ChEMBL_741139 (CHEMBL1764410)
IC50
2800±n/a nM
Citation
 Hong, Q; Bakshi, RK; Palucki, BL; Park, MK; Ye, Z; He, S; Pollard, PG; Sebhat, IK; Liu, J; Guo, L; Cashen, DE; Martin, WJ; Weinberg, DH; MacNeil, T; Tang, R; Tamvakopoulos, C; Peng, Q; Miller, RR; Stearns, RA; Chen, HY; Chen, AS; Strack, AM; Fong, TM; MacIntyre, DE; Wyvratt, MJ; Nargund, RP Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Bioorg Med Chem Lett 21:2330-4 (2011) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MC1R | MSH-R | MSHR | MSHR_HUMAN | Melanocortin MC1 | Melanocortin receptor (M1 and M4) | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R)
Type:
Enzyme
Mol. Mass.:
34717.23
Organism:
Homo sapiens (Human)
Description:
Q01726
Residue:
317
Sequence:
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
  
Inhibitor
Name:
BDBM50340461
Synonyms:
CHEMBL1762008 | Trans-(3R,5R)-N-((R)-1-(4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl)-3-(4-fluorophenyl)-1-oxopropan-2-yl)-3,5-diethylpiperazine-1-carboxamide
Type:
Small organic molecule
Emp. Form.:
C34H54FN5O3
Mol. Mass.:
599.8227
SMILES:
CC[C@@H]1CN(C[C@@H](CC)N1)C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C |r|
Structure:
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