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Target
Aurora kinase A
Ligand
BDBM50340956
Substrate
n/a
Meas. Tech.
ChEMBL_740044 (CHEMBL1763104)
IC50
6200±n/a nM
Citation
 Zagotto, G; Redaelli, M; Pasquale, R; D'Avella, D; Cozza, G; Denaro, L; Pizzato, F; Mucignat-Caretta, C 8-Hydroxynaphthalene-1,4-dione derivative as novel compound for glioma treatment. Bioorg Med Chem Lett 21:2079-82 (2011) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM50340956
Synonyms:
5,8-dihydroxy-2-(2,3,4-trihydroxyphenyl)naphthalene-1,4-dione | CHEMBL1762119
Type:
Small organic molecule
Emp. Form.:
C16H10O7
Mol. Mass.:
314.2464
SMILES:
Oc1ccc(C2=CC(=O)c3c(O)ccc(O)c3C2=O)c(O)c1O |t:5|
Structure:
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