Reaction Details Report a problem with these data
Target
Bombesin receptor subtype-3
Ligand
BDBM50340973
Substrate
n/a
Meas. Tech.
ChEMBL_740070 (CHEMBL1763130)
IC50
>10000±n/a nM
Citation
 Lo, MM; Chobanian, HR; Palyha, O; Kan, Y; Kelly, TM; Guan, XM; Reitman, ML; Dragovic, J; Lyons, KA; Nargund, RP; Lin, LS Pyridinesulfonylureas and pyridinesulfonamides as selective bombesin receptor subtype-3 (BRS-3) agonists. Bioorg Med Chem Lett 21:2040-3 (2011) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS-3 | BRS3 | BRS3_HUMAN | Bombesin 3 | Bombesin like receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44424.45
Organism:
Homo sapiens (Human)
Description:
Bombesin 3 BRS3 HUMAN::P32247
Residue:
399
Sequence:
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
  
Inhibitor
Name:
BDBM50340973
Synonyms:
(R)-N-(tert-butylcarbamoyl)-4-(quinuclidin-3-ylamino)pyridine-3-sulfonamide | CHEMBL1762256
Type:
Small organic molecule
Emp. Form.:
C17H27N5O3S
Mol. Mass.:
381.493
SMILES:
CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1CN2CCC1CC2 |r,wU:18.18,(25.92,-38.56,;24.59,-39.33,;24.59,-40.87,;25.92,-40.11,;23.26,-38.57,;21.93,-39.34,;21.93,-40.88,;20.59,-38.57,;19.26,-39.34,;18.47,-40.67,;20.02,-40.67,;17.93,-38.57,;17.93,-37.03,;16.59,-36.27,;15.26,-37.03,;15.26,-38.57,;16.59,-39.35,;16.59,-40.88,;15.26,-41.66,;15.26,-43.19,;13.91,-43.96,;12.59,-43.18,;12.59,-41.65,;13.92,-40.88,;13.14,-42.2,;14.62,-42.59,)|
Structure:
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