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Target
Adenosine receptor A3
Ligand
BDBM50086153
Substrate
n/a
Meas. Tech.
ChEMBL_742836 (CHEMBL1769839)
Ki
490±n/a nM
Citation
 Poli, D; Catarzi, D; Colotta, V; Varano, F; Filacchioni, G; Daniele, S; Trincavelli, L; Martini, C; Paoletta, S; Moro, S The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists. J Med Chem 54:2102-13 (2011) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50086153
Synonyms:
4-Amino-2-phenyl-2H-[1,2,4]triazolo[4,3-a]quinoxalin-1-one | 4-amino-2-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-1(2H)-one | CHEMBL278197
Type:
Small organic molecule
Emp. Form.:
C15H11N5O
Mol. Mass.:
277.2807
SMILES:
Nc1nc2ccccc2n2c1nn(-c1ccccc1)c2=O
Structure:
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