Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50341920
Substrate
n/a
Meas. Tech.
ChEMBL_743423 (CHEMBL1767777)
IC50
>17000±n/a nM
Citation
Manley, PJ; Zartman, A; Paone, DV; Burgey, CS; Henze, DA; Della Penna, K; Desai, R; Leitl, MD; Lemaire, W; White, RB; Yeh, S; Urban, MO; Kane, SA; Hartman, GD; Bilodeau, MT; Trotter, BW Decahydroquinoline amides as highly selective CB2 agonists: role of selectivity on in vivo efficacy in a rodent model of analgesia. Bioorg Med Chem Lett 21:2359-64 (2011) [PubMed] Article
More Info.:
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
Inhibitor
Name:
BDBM50341920
Synonyms:
((4aR,8aS)-4-hydroxy-4-phenyloctahydroquinolin-1(2H)-yl)(2-(pyridin-4-yl)thiazol-4-yl)methanone | ((4aR,8aS)-4-hydroxy-4-phenyloctahydroquinolin-1(2H)-yl)(pyridin-2-yl)methanone | (3-(2-fluorophenyl)-1H-pyrazol-5-yl)((4aR,8aS)-4-hydroxy-4-phenyloctahydroquinolin-1(2H)-yl)methanone | CHEMBL1765092
Type:
Small organic molecule
Emp. Form.:
C24H25N3O2S
Mol. Mass.:
419.539
SMILES:
OC1(CCN([C@H]2CCCC[C@@H]12)C(=O)c1csc(n1)-c1ccncc1)c1ccccc1 |r|