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Target
Neurotensin receptor type 1
Ligand
BDBM50342254
Substrate
n/a
Meas. Tech.
ChEMBL_743646 (CHEMBL1768189)
Ki
17±n/a nM
Citation
 Einsiedel, J; Held, C; Hervet, M; Plomer, M; Tschammer, N; Hübner, H; Gmeiner, P Discovery of highly potent and neurotensin receptor 2 selective neurotensin mimetics. J Med Chem 54:2915-23 (2011) [PubMed]  Article 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM50342254
Synonyms:
(S)-2-((2S,3S)-2-((S)-2-((S)-1-(2-((S)-2,6-diamino-N-(4-aminobutyl)hexanamido)acetyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid | CHEMBL411195 | Lys-NLys-Pro-Tyr-Ile-Leu-OH
Type:
Small organic molecule
Emp. Form.:
C38H64N8O8
Mol. Mass.:
760.9636
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)CN(CCCCN)C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O
Structure:
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