Reaction Details
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Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50342788
Substrate
n/a
Meas. Tech.
ChEMBL_744419 (CHEMBL1772373)
IC50
1740000±n/a nM
Citation
Mravljak, J; Monasson, O; Al-Dabbagh, B; Crouvoisier, M; Bouhss, A; Gravier-Pelletier, C; Le Merrer, Y Synthesis and biological evaluation of a diazepanone-based library of liposidomycins analogs as MraY inhibitors. Eur J Med Chem 46:1582-92 (2011) [PubMed] Article More Info.:
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_STAAU | mraY
Type:
PROTEIN
Mol. Mass.:
35238.55
Organism:
Staphylococcus aureus (strain MRSA252)
Description:
ChEMBL_827497
Residue:
321
Sequence:
MIFVYALLALVITFVLVPVLIPTLKRMKFGQSIREEGPQSHMKKTGTPTMGGLTFLLSIVITSLVAIIFVDQANPIILLLFVTIGFGLIGFIDDYIIVVKKNNQGLTSKQKFLAQIGIAIIFFVLSNVFHLVNFSTSIHIPFTNVAIPLSFAYVIFIVFWQVGFSNAVNLTDGLDGLATGLSIIGFTMYAIMSFVLGETAIGIFCIIMLFALLGFLPYNINPAKVFMGDTGSLALGGIFATISIMLNQELSLIFIGLVFVIETLSVMLQVASFKLTGKRIFKMSPIHHHFELIGWSEWKVVTVFWAVGLISGLIGLWIGVH
Inhibitor
Name:
BDBM50342788
Synonyms:
(3S,6S,7R)-3,7-Dihydroxymethyl-4-N-methyl-6-palmitoyloxy-1,4-diazepan-2-one | CHEMBL1770421
Type:
Small organic molecule
Emp. Form.:
C24H46N2O5
Mol. Mass.:
442.6324
SMILES:
CCCCCCCCCCCCCCCC(=O)O[C@H]1CN(C)[C@@H](CO)C(=O)N[C@@H]1CO |r|
Structure:
