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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50343505
Substrate
n/a
Meas. Tech.
ChEMBL_746462 (CHEMBL1776378)
IC50
6.0±n/a nM
Citation
 Bühler, S; Goettert, M; Schollmeyer, D; Albrecht, W; Laufer, SA Chiral sulfoxides as metabolites of 2-thioimidazole-based p38a mitogen-activated protein kinase inhibitors: enantioselective synthesis and biological evaluation. J Med Chem 54:3283-97 (2011) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50343505
Synonyms:
(S)-4-(4-(4-fluorophenyl)-2-(isopropylsulfinyl)-1H-imidazol-5-yl)-N-isopropylpyridin-2-amine | CHEMBL1773499
Type:
Small organic molecule
Emp. Form.:
C20H23FN4OS
Mol. Mass.:
386.486
SMILES:
CC(C)Nc1cc(ccn1)-c1nc([nH]c1-c1ccc(F)cc1)[S@@](=O)C(C)C |r|
Structure:
Search PDB for entries with ligand similarity: