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Target
Histamine H3 receptor
Ligand
BDBM50343839
Substrate
n/a
Meas. Tech.
ChEMBL_747648 (CHEMBL1777266)
Ki
20±n/a nM
Citation
 Wiecek, M; Kottke, T; Ligneau, X; Schunack, W; Seifert, R; Stark, H; Handzlik, J; Kiec-Kononowicz, K N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands. Bioorg Med Chem 19:2850-8 (2011) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50343839
Synonyms:
(E)-3-(1H-Imidazol-4-yl)propyl3,7-dimethylocta-2,6-dienylcarbamate hydrogenmaleate | CHEMBL1774597
Type:
Small organic molecule
Emp. Form.:
C17H27N3O2
Mol. Mass.:
305.4152
SMILES:
CC(C)=CCC\C(C)=C\CNC(=O)OCCCc1cnc[nH]1 |(49.85,-16.23,;48.52,-15.46,;48.51,-13.92,;47.18,-16.23,;45.85,-15.46,;44.52,-16.24,;43.19,-15.46,;43.18,-13.94,;41.85,-16.23,;40.52,-15.46,;39.19,-16.23,;37.86,-15.45,;37.87,-13.91,;36.53,-16.22,;35.2,-15.44,;33.87,-16.21,;32.54,-15.44,;31.21,-16.21,;31.05,-17.74,;29.55,-18.06,;28.78,-16.73,;29.8,-15.59,)|
Structure:
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