Reaction Details Report a problem with these data
Target
Interstitial collagenase
Ligand
BDBM50345518
Substrate
n/a
Meas. Tech.
ChEMBL_751104 (CHEMBL1787041)
IC50
>10000±n/a nM
Citation
De Savi, C; Pape, A; Sawyer, Y; Milne, D; Davies, C; Cumming, JG; Ting, A; Lamont, S; Smith, PD; Tart, J; Page, K; Moore, P Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis. Bioorg Med Chem Lett 21:3301-6 (2011) [PubMed] Article
More Info.:
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Inhibitor
Name:
BDBM50345518
Synonyms:
CHEMBL1784343 | N-(1-((4-(2-(3,5-dimethylisoxazol-4-yl)ethyl)piperidin-1-ylsulfonyl)methyl)cyclobutyl)-N-hydroxyformamide | US10322143, Compound 14c
Type:
Small organic molecule
Emp. Form.:
C18H29N3O5S
Mol. Mass.:
399.505
SMILES:
Cc1noc(C)c1CCC1CCN(CC1)S(=O)(=O)CC1(CCC1)N(O)C=O