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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50347097
Substrate
n/a
Meas. Tech.
ChEMBL_752994 (CHEMBL1798818)
IC50
30±n/a nM
Citation
 Selness, SR; Boehm, TL; Walker, JK; Devadas, B; Durley, RC; Kurumbail, R; Shieh, H; Xing, L; Hepperle, M; Rucker, PV; Jerome, KD; Benson, AG; Marrufo, LD; Madsen, HM; Hitchcock, J; Owen, TJ; Christie, L; Promo, MA; Hickory, BS; Alvira, E; Naing, W; Blevis-Bal, R; Devraj, RV; Messing, D; Schindler, JF; Hirsch, J; Saabye, M; Bonar, S; Webb, E; Anderson, G; Monahan, JB Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase. Bioorg Med Chem Lett 21:4059-65 (2011) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50347097
Synonyms:
CHEMBL1797125
Type:
Small organic molecule
Emp. Form.:
C19H14BrCl2NO2
Mol. Mass.:
439.13
SMILES:
Cc1cc(OCc2ccccc2)c(Br)c(=O)n1-c1c(Cl)cccc1Cl |(2.07,-8.4,;.74,-9.16,;-.59,-8.39,;-1.92,-9.16,;-3.26,-8.4,;-4.59,-9.17,;-5.92,-8.4,;-5.92,-6.87,;-7.26,-6.1,;-8.59,-6.87,;-8.58,-8.42,;-7.24,-9.18,;-1.92,-10.7,;-3.25,-11.48,;-.59,-11.47,;-.59,-13.01,;.74,-10.7,;2.07,-11.48,;3.39,-10.71,;3.39,-9.17,;4.73,-11.47,;4.73,-13.02,;3.39,-13.79,;2.06,-13.02,;.73,-13.78,)|
Structure:
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