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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50347102
Substrate
n/a
Meas. Tech.
ChEMBL_752994 (CHEMBL1798818)
IC50
23±n/a nM
Citation
 Selness, SR; Boehm, TL; Walker, JK; Devadas, B; Durley, RC; Kurumbail, R; Shieh, H; Xing, L; Hepperle, M; Rucker, PV; Jerome, KD; Benson, AG; Marrufo, LD; Madsen, HM; Hitchcock, J; Owen, TJ; Christie, L; Promo, MA; Hickory, BS; Alvira, E; Naing, W; Blevis-Bal, R; Devraj, RV; Messing, D; Schindler, JF; Hirsch, J; Saabye, M; Bonar, S; Webb, E; Anderson, G; Monahan, JB Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase. Bioorg Med Chem Lett 21:4059-65 (2011) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50347102
Synonyms:
CHEMBL1797205
Type:
Small organic molecule
Emp. Form.:
C24H22ClF4N3O2
Mol. Mass.:
495.897
SMILES:
CN1CCN(CC1)c1cc(F)c(c(F)c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O |(32.8,-38.3,;31.47,-37.53,;30.13,-38.29,;28.8,-37.52,;28.81,-35.99,;30.14,-35.21,;31.47,-35.99,;27.48,-35.22,;27.48,-33.67,;26.14,-32.9,;26.14,-31.36,;24.82,-33.67,;24.81,-35.21,;23.48,-35.98,;26.14,-35.98,;23.49,-32.9,;23.49,-31.36,;24.82,-30.59,;22.16,-30.58,;20.83,-31.36,;19.49,-30.59,;18.16,-31.37,;16.83,-30.6,;15.51,-31.38,;14.17,-30.62,;14.16,-29.07,;12.82,-28.31,;15.49,-28.3,;16.83,-29.06,;18.16,-28.29,;20.83,-32.9,;19.5,-33.67,;22.16,-33.66,;22.16,-35.2,)|
Structure:
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