Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 14
Ligand
BDBM50347108
Substrate
n/a
Meas. Tech.
ChEMBL_752994 (CHEMBL1798818)
IC50
8±n/a nM
Citation
 Selness, SR; Boehm, TL; Walker, JK; Devadas, B; Durley, RC; Kurumbail, R; Shieh, H; Xing, L; Hepperle, M; Rucker, PV; Jerome, KD; Benson, AG; Marrufo, LD; Madsen, HM; Hitchcock, J; Owen, TJ; Christie, L; Promo, MA; Hickory, BS; Alvira, E; Naing, W; Blevis-Bal, R; Devraj, RV; Messing, D; Schindler, JF; Hirsch, J; Saabye, M; Bonar, S; Webb, E; Anderson, G; Monahan, JB Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase. Bioorg Med Chem Lett 21:4059-65 (2011) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50347108
Synonyms:
CHEMBL1797211
Type:
Small organic molecule
Emp. Form.:
C19H12ClF4NO3
Mol. Mass.:
413.75
SMILES:
OCc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1-c1c(F)cccc1F |(28.8,-8.57,;28.8,-10.11,;27.46,-10.87,;26.13,-10.1,;24.8,-10.87,;23.47,-10.11,;22.14,-10.88,;20.8,-10.12,;19.48,-10.89,;18.14,-10.13,;18.14,-8.58,;16.8,-7.82,;19.47,-7.81,;20.8,-8.58,;22.14,-7.81,;24.8,-12.41,;23.47,-13.19,;26.13,-13.18,;26.13,-14.72,;27.46,-12.41,;28.79,-13.19,;30.12,-12.42,;30.11,-10.88,;31.45,-13.18,;31.45,-14.73,;30.12,-15.5,;28.79,-14.73,;27.45,-15.49,)|
Structure:
Search PDB for entries with ligand similarity: