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Target
Serine/threonine-protein kinase Nek2
Ligand
BDBM50347865
Substrate
n/a
Meas. Tech.
ChEMBL_756564 (CHEMBL1804637)
IC50
20±n/a nM
Citation
 Henise, JC; Taunton, J Irreversible Nek2 kinase inhibitors with cellular activity. J Med Chem 54:4133-46 (2011) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Nek2
Synonyms:
NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1
Type:
Enzyme
Mol. Mass.:
51776.96
Organism:
Homo sapiens (Human)
Description:
P51955
Residue:
445
Sequence:
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR
  
Inhibitor
Name:
BDBM50347865
Synonyms:
CHEMBL1802383
Type:
Small organic molecule
Emp. Form.:
C15H12ClN3O2
Mol. Mass.:
301.728
SMILES:
Cc1nc[nH]c1C=C1C(=O)Nc2ccc(cc12)C(=O)CCl |w:6.6|
Structure:
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