Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 3
Ligand
BDBM50349677
Substrate
n/a
Meas. Tech.
ChEMBL_760041 (CHEMBL1810317)
IC50
40±n/a nM
Citation
 Thoma, G; Baenteli, R; Lewis, I; Jones, D; Kovarik, J; Streiff, MB; Zerwes, HG Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood. Bioorg Med Chem Lett 21:4745-9 (2011) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 3
Synonyms:
CXCR3_RAT | Cxcr3
Type:
PROTEIN
Mol. Mass.:
40937.37
Organism:
Rattus norvegicus
Description:
ChEMBL_760041
Residue:
367
Sequence:
MYLEVSERQVLDASDIAFLLENSTSPYDYGENESDFSDSPPCPQDFSLNFDRTFLPVLYSLLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLVLTLPLWAVDAAAQWVFGSGLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATQIYRRDPWVRVALTCIVVWGLCVLFALPDFIFLSASHDQRLNATHCQYNFPQVGRTALRVLQLVAGFLMPLLVMAYCYAHILAVLLVSRGQRRFRAMRLVVVVVVAFAVCWTPYHLVVLVDILMDVGVLARNCGRESHVDVAKSVTSGMGYMHCCLNPLLYAFVGVKFKEQMWMLLMRLGRSDQRGPQRQPSSSRRESSWSETTEASYLGL
  
Inhibitor
Name:
BDBM50349677
Synonyms:
CHEMBL1809043
Type:
Small organic molecule
Emp. Form.:
C32H37N5O3
Mol. Mass.:
539.6679
SMILES:
O=C(Nc1ccccc1)N1C[C@@H](C=C2[C@H]1Cc1cn(CCN3CCOCC3)c3cccc2c13)C(=O)N1CCCC1 |r,c:13|
Structure:
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