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Target
Phospholipase A2, membrane associated
Ligand
BDBM23738
Substrate
n/a
Meas. Tech.
ChEMBL_761580 (CHEMBL1815898)
IC50
1000±n/a nM
Citation
 Wu, Y; Chen, Z; Liu, Y; Yu, L; Zhou, L; Yang, S; Lai, L Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A2 inhibitors. Bioorg Med Chem 19:3361-6 (2011) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM23738
Synonyms:
2-(1-benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetamide | CHEMBL346855 | Indole Derivative, 1
Type:
Small organic molecule
Emp. Form.:
C19H20N2O2
Mol. Mass.:
308.3743
SMILES:
COc1ccc2n(Cc3ccccc3)c(C)c(CC(N)=O)c2c1
Structure:
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