Target
Glutamate receptor ionotropic, kainate 2
Ligand
BDBM50252922
Substrate
n/a
Meas. Tech.
ChEMBL_761798 (CHEMBL1817065)
Ki
>1000000±n/a nM
Citation
 Venskutonyte, RButini, SCoccone, SSGemma, SBrindisi, MKumar, VGuarino, EMaramai, SValenti, SAmir, AValadés, EAFrydenvang, KKastrup, JSNovellino, ECampiani, GPickering, DS Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. J Med Chem 54:4793-805 (2011) [PubMed]  Article 
Target
Name:
Glutamate receptor ionotropic, kainate 2
Synonyms:
GRIK2_RAT | Glur6 | Glutamate receptor ionotropic kainate 2 | Grik2 | Ionotropic glutamate receptor kainate 2/5
Type:
PROTEIN
Mol. Mass.:
102478.61
Organism:
Rattus norvegicus
Description:
ChEMBL_936439
Residue:
908
Sequence:
MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA
  
Inhibitor
Name:
BDBM50252922
Synonyms:
(S)-1-(2'-Amino-2'-carboxyethyl)thieno[3,2-d]pyrimidin-2,4-dione | CHEMBL492630
Type:
Small organic molecule
Emp. Form.:
C9H9N3O4S
Mol. Mass.:
255.25
SMILES:
N[C@@H](Cn1c2ccsc2c(=O)[nH]c1=O)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: