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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50351384
Substrate
n/a
Meas. Tech.
ChEMBL_764455 (CHEMBL1821007)
IC50
820±n/a nM
Citation
 Saito, T; Obitsu, T; Kondo, T; Matsui, T; Nagao, Y; Kusumi, K; Matsumura, N; Ueno, S; Kishi, A; Katsumata, S; Kagamiishi, Y; Nakai, H; Toda, M 6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem 19:5432-45 (2011) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50351384
Synonyms:
CHEMBL1819074
Type:
Small organic molecule
Emp. Form.:
C23H30N4
Mol. Mass.:
362.5111
SMILES:
CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1cc(C)ccc1C |(38.64,4.34,;37.29,3.6,;37.26,2.06,;38.58,1.26,;39.93,2.01,;35.91,1.31,;35.88,-.23,;34.53,-.97,;33.07,-.47,;32.14,-1.7,;33.03,-2.96,;34.5,-2.51,;35.83,-3.31,;37.18,-2.55,;38.64,-3.04,;39.56,-1.81,;41.1,-1.83,;38.67,-.56,;37.2,-1.02,;39.1,-4.51,;38.05,-5.64,;38.51,-7.11,;37.46,-8.24,;40.01,-7.45,;41.06,-6.31,;40.6,-4.85,;41.64,-3.71,)|
Structure:
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