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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50351390
Substrate
n/a
Meas. Tech.
ChEMBL_764455 (CHEMBL1821007)
IC50
71±n/a nM
Citation
 Saito, T; Obitsu, T; Kondo, T; Matsui, T; Nagao, Y; Kusumi, K; Matsumura, N; Ueno, S; Kishi, A; Katsumata, S; Kagamiishi, Y; Nakai, H; Toda, M 6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem 19:5432-45 (2011) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50351390
Synonyms:
CHEMBL1819080
Type:
Small organic molecule
Emp. Form.:
C23H29ClN4O
Mol. Mass.:
412.956
SMILES:
CCOc1ccc(-c2c(C)nn3c(NC(CC)CC)c4CCCc4nc23)c(Cl)c1 |(11.29,-47.27,;10.83,-45.8,;11.87,-44.67,;11.41,-43.2,;9.91,-42.86,;9.45,-41.39,;10.5,-40.26,;10.04,-38.79,;10.96,-37.56,;12.5,-37.58,;10.07,-36.31,;8.6,-36.76,;7.29,-35.97,;7.31,-34.43,;8.66,-33.69,;8.69,-32.15,;10.04,-31.4,;9.98,-34.48,;11.33,-33.74,;5.93,-36.72,;4.48,-36.21,;3.55,-37.44,;4.43,-38.71,;5.9,-38.26,;7.23,-39.06,;8.58,-38.3,;12,-40.59,;13.04,-39.46,;12.46,-42.06,)|
Structure:
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