Reaction Details Report a problem with these data
Target
Transcriptional activator protein LuxR
Ligand
BDBM50266165
Substrate
n/a
Meas. Tech.
ChEMBL_765232 (CHEMBL1827785)
IC50
610±n/a nM
Citation
 Lowery, CA; Salzameda, NT; Sawada, D; Kaufmann, GF; Janda, KD Medicinal chemistry as a conduit for the modulation of quorum sensing. J Med Chem 53:7467-89 (2010) [PubMed]  Article 
Target
Name:
Transcriptional activator protein LuxR
Synonyms:
LUXR_ALIFS | luxR
Type:
PROTEIN
Mol. Mass.:
28563.86
Organism:
Vibrio fischeri
Description:
ChEMBL_831639
Residue:
250
Sequence:
MKNINADDTYRIINKIKACRSNNDINQCLSDMTKMVHCEYYLLAIIYPHSMVKSDISILDNYPKKWRQYYDDANLIKYDPIVDYSNSNHSPINWNIFENNAVNKKSPNVIKEAKTSGLITGFSFPIHTANNGFGMLSFAHSEKDNYIDSLFLHACMNIPLIVPSLVDNYRKINIANNKSNNDLTKREKECLAWACEGKSSWDISKILGCSERTVTFHLTNAQMKLNTTNRCQSISKAILTGAIDCPYFKN
  
Inhibitor
Name:
BDBM50266165
Synonyms:
(S)-N-(2-oxotetrahydrofuran-3-yl)-2-(4-(trifluoromethyl)phenyl)acetamide | CHEMBL468624
Type:
Small organic molecule
Emp. Form.:
C13H12F3NO3
Mol. Mass.:
287.2345
SMILES:
FC(F)(F)c1ccc(CC(=O)N[C@H]2CCOC2=O)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: