Reaction Details Report a problem with these data
Target
Toll-like receptor 4
Ligand
BDBM50351544
Substrate
n/a
Meas. Tech.
ChEMBL_765884 (CHEMBL1827810)
IC50
15600±n/a nM
Citation
 Chavez, SA; Martinko, AJ; Lau, C; Pham, MN; Cheng, K; Bevan, DE; Mollnes, TE; Yin, H Development ofß-amino alcohol derivatives that inhibit Toll-like receptor 4 mediated inflammatory response as potential antiseptics. J Med Chem 54:4659-69 (2011) [PubMed]  Article 
Target
Name:
Toll-like receptor 4
Synonyms:
CD_antigen=CD284 | Lps | TLR4_MOUSE | Tlr4 | Toll-like receptor 4 | Toll-like receptor 4/Ly96 | Toll-like receptor 4/MD-2/CD14
Type:
PROTEIN
Mol. Mass.:
95518.84
Organism:
Mus musculus
Description:
ChEMBL_1496719
Residue:
835
Sequence:
MMPPWLLARTLIMALFFSCLTPGSLNPCIEVVPNITYQCMDQKLSKVPDDIPSSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIHSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLEDVPKHFKWQSLSIIRCQLKQFPTLDLPFLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFMGLEELQHLDFQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLVNVEQMTCATPVEMNTSLVLDFNNSTCYMYKTIISVSVVSVIVVSTVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRHIFWRRLKNALLDGKASNPEQTAEEEQETATWT
  
Inhibitor
Name:
BDBM50351544
Synonyms:
CHEMBL1821757
Type:
Small organic molecule
Emp. Form.:
C23H27Cl2N3O2
Mol. Mass.:
448.385
SMILES:
CN(C[C@H](O)COc1ccc(Cl)cc1)Cc1c(C)nn(Cc2ccccc2Cl)c1C |r|
Structure:
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