Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50351944
Substrate
n/a
Meas. Tech.
ChEMBL_766014 (CHEMBL1828143)
IC50
279.5±n/a nM
Citation
 Huang, WJ; Chen, CC; Chao, SW; Yu, CC; Yang, CY; Guh, JH; Lin, YC; Kuo, CI; Yang, P; Chang, CI Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors. Eur J Med Chem 46:4042-9 (2011) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50351944
Synonyms:
CHEMBL1822043
Type:
Small organic molecule
Emp. Form.:
C22H36N2O6
Mol. Mass.:
424.531
SMILES:
CC(C)CCc1c(O)c(CCC(=O)NO)ccc1OCCCCCCCC(=O)NO
Structure:
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