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Target
Tyrosine-protein kinase HCK
Ligand
BDBM50354481
Substrate
n/a
Meas. Tech.
ChEMBL_771567 (CHEMBL1837746)
Ki
5000±n/a nM
Citation
 Radi, M; Brullo, C; Crespan, E; Tintori, C; Musumeci, F; Biava, M; Schenone, S; Dreassi, E; Zamperini, C; Maga, G; Pagano, D; Angelucci, A; Bologna, M; Botta, M Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells. Bioorg Med Chem Lett 21:5928-33 (2011) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase HCK
Synonyms:
HCK | HCK_HUMAN | Hematopoietic cell kinase | Hemopoietic cell kinase | p59-HCK/p60-HCK | p59Hck | p61Hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59600.18
Organism:
Homo sapiens (Human)
Description:
P08631
Residue:
526
Sequence:
MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
  
Inhibitor
Name:
BDBM50354481
Synonyms:
CHEMBL1836679
Type:
Small organic molecule
Emp. Form.:
C21H20ClN5S
Mol. Mass.:
409.935
SMILES:
CSc1nc(Nc2cccc(Cl)c2)c2cnn(CC(C)c3ccccc3)c2n1
Structure:
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