Reaction Details
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Toll-like receptor 4
Ligand
BDBM50355887
Substrate
n/a
Meas. Tech.
ChEMBL_775690 (CHEMBL1913432)
IC50
28800±n/a nM
Citation
Ainge, GD; Martin, WJ; Compton, BJ; Hayman, CM; Larsen, DS; Yoon, SI; Wilson, IA; Harper, JL; Painter, GF Synthesis and Toll-like receptor 4 (TLR4) activity of phosphatidylinositol dimannoside analogues. J Med Chem 54:7268-79 (2011) [PubMed] Article More Info.:
Target
Name:
Toll-like receptor 4
Synonyms:
CD_antigen=CD284 | Lps | TLR4_MOUSE | Tlr4 | Toll-like receptor 4 | Toll-like receptor 4/Ly96 | Toll-like receptor 4/MD-2/CD14
Type:
PROTEIN
Mol. Mass.:
95518.84
Organism:
Mus musculus
Description:
ChEMBL_1496719
Residue:
835
Sequence:
MMPPWLLARTLIMALFFSCLTPGSLNPCIEVVPNITYQCMDQKLSKVPDDIPSSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIHSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLEDVPKHFKWQSLSIIRCQLKQFPTLDLPFLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFMGLEELQHLDFQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLVNVEQMTCATPVEMNTSLVLDFNNSTCYMYKTIISVSVVSVIVVSTVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRHIFWRRLKNALLDGKASNPEQTAEEEQETATWT
Inhibitor
Name:
BDBM50355887
Synonyms:
CHEMBL1910029
Type:
Small organic molecule
Emp. Form.:
C53H101O22P
Mol. Mass.:
1121.3296
SMILES:
CCCCCCCCCCCCCCCCOC[C@H](COP(O)(=O)O[C@H]1[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O)OC(=O)CCCCCCCCCCCCCCC |r|
Structure:
