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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50325537
Substrate
n/a
Meas. Tech.
ChEMBL_795920 (CHEMBL1936793)
IC50
10000±n/a nM
Citation
 Smith, JR; Evans, KJ; Wright, A; Willows, RD; Jamie, JF; Griffith, R Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen. Bioorg Med Chem 20:1354-63 (2012) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50325537
Synonyms:
CHEMBL1224310 | CHEMBL1229095 | S-(2-Chlorobenzyl)isothiourea hydrochloride | cid_199161
Type:
Small organic molecule
Emp. Form.:
C8H9ClN2S
Mol. Mass.:
200.688
SMILES:
NC(=N)SCc1ccccc1Cl
Structure:
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