Reaction Details Report a problem with these data
Target
Prostaglandin E synthase
Ligand
BDBM50360832
Substrate
n/a
Meas. Tech.
ChEMBL_796762 (CHEMBL1938077)
IC50
9.1±n/a nM
Citation
 Shiro, T; Takahashi, H; Kakiguchi, K; Inoue, Y; Masuda, K; Nagata, H; Tobe, M Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E2 synthase-1 inhibitors. Bioorg Med Chem Lett 22:285-8 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50360832
Synonyms:
CHEMBL1934810
Type:
Small organic molecule
Emp. Form.:
C16H9BrClN3O
Mol. Mass.:
374.619
SMILES:
Clc1ccccc1-c1nc2c([nH]1)c(=O)[nH]c1cc(Br)ccc21
Structure:
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