Reaction Details Report a problem with these data
Target
Natural resistance-associated macrophage protein 2
Ligand
BDBM54072
Substrate
n/a
Meas. Tech.
ChEMBL_795244 (CHEMBL1936903)
IC50
2570±n/a nM
Citation
Cadieux, JA; Zhang, Z; Mattice, M; Brownlie-Cutts, A; Fu, J; Ratkay, LG; Kwan, R; Thompson, J; Sanghara, J; Zhong, J; Goldberg, YP Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett 22:90-5 (2011) [PubMed] Article
More Info.:
Target
Name:
Natural resistance-associated macrophage protein 2
Synonyms:
DCT1 | DMT-1 | DMT1 | Divalent cation transporter 1 | Divalent metal transporter 1 | NRAM2_HUMAN | NRAMP 2 | NRAMP2 | SLC11A2
Type:
PROTEIN
Mol. Mass.:
62262.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_795244
Residue:
568
Sequence:
MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTCHLGLTAQPELYLLNTMDADSLVSR
Inhibitor
Name:
BDBM54072
Synonyms:
3-[(4Z)-4-[4-(diethylamino)benzylidene]-5-keto-3-methyl-2-pyrazolin-1-yl]-6-methyl-2H-1,2,4-triazin-5-one | 3-[(4Z)-4-[[4-(diethylamino)phenyl]methylidene]-3-methyl-5-oxidanylidene-pyrazol-1-yl]-6-methyl-2H-1,2,4-triazin-5-one | 3-[(4Z)-4-[[4-(diethylamino)phenyl]methylidene]-3-methyl-5-oxo-1-pyrazolyl]-6-methyl-2H-1,2,4-triazin-5-one | 3-[(4Z)-4-[[4-(diethylamino)phenyl]methylidene]-3-methyl-5-oxopyrazol-1-yl]-6-methyl-2H-1,2,4-triazin-5-one | 3-{4-[1-(4-Diethylamino-phenyl)-meth-(Z)-ylidene]-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl}-6-methyl-4H -[1,2,4]triazin-5-one | CHEMBL1548704 | MLS000777021 | SMR000413411 | cid_5710537
Type:
Small organic molecule
Emp. Form.:
C19H22N6O2
Mol. Mass.:
366.417
SMILES:
CCN(CC)c1ccc(C=c2c(=C)[nH]n(-c3nnc(C)c(=O)[nH]3)c2=O)cc1 |w:9.8|