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Target
Prostaglandin E synthase
Ligand
BDBM50060279
Substrate
n/a
Meas. Tech.
ChEMBL_794980 (CHEMBL1936307)
IC50
800±n/a nM
Citation
 Wiegard, A; Hanekamp, W; Griessbach, K; Fabian, J; Lehr, M Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E2 synthase-1. Eur J Med Chem 48:153-63 (2012) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50060279
Synonyms:
3-(4-Dodecanoyl-1,3,5-trimethyl-1H-pyrrol-2-yl)-propionic acid | CHEMBL442012
Type:
Small organic molecule
Emp. Form.:
C22H37NO3
Mol. Mass.:
363.5341
SMILES:
CCCCCCCCCCCC(=O)c1c(C)c(CCC(O)=O)n(C)c1C
Structure:
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