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Target
Acyl-CoA desaturase 1
Ligand
BDBM50362587
Substrate
n/a
Meas. Tech.
ChEMBL_798097 (CHEMBL1943234)
IC50
21±n/a nM
Citation
 Lachance, N; Gareau, Y; Guiral, S; Huang, Z; Isabel, E; Leclerc, JP; Léger, S; Martins, E; Nadeau, C; Oballa, RM; Ouellet, SG; Powell, DA; Ramtohul, YK; Tranmer, GK; Trinh, T; Wang, H; Zhang, L Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series. Bioorg Med Chem Lett 22:980-4 (2012) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_MOUSE | Scd1
Type:
PROTEIN
Mol. Mass.:
41064.54
Organism:
Mus musculus
Description:
ChEMBL_1462109
Residue:
355
Sequence:
MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50362587
Synonyms:
CHEMBL1938875
Type:
Small organic molecule
Emp. Form.:
C16H15ClFN7O2S
Mol. Mass.:
423.852
SMILES:
OC(=O)Cn1nnc(n1)-c1cnc(s1)N1CCN(CC1)c1cc(F)ccc1Cl
Structure:
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