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Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM50363783
Substrate
n/a
Meas. Tech.
ChEMBL_801933 (CHEMBL1947692)
IC50
4600±n/a nM
Citation
 McCarthy, AR; Pirrie, L; Hollick, JJ; Ronseaux, S; Campbell, J; Higgins, M; Staples, OD; Tran, F; Slawin, AM; Lain, S; Westwood, NJ Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins. Bioorg Med Chem 20:1779-93 (2012) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM50363783
Synonyms:
CHEMBL1945265 | US9365508, 361a (3-Br, 4 tBu)
Type:
Small organic molecule
Emp. Form.:
C25H33BrN4O2S
Mol. Mass.:
533.524
SMILES:
CN(C)CCCCC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(c(Br)c2)C(C)(C)C)cc1
Structure:
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