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Target
Endothelial lipase
Ligand
BDBM50364299
Substrate
n/a
Meas. Tech.
ChEMBL_804415 (CHEMBL1954842)
IC50
2800±n/a nM
Citation
 O'Connell, DP; LeBlanc, DF; Cromley, D; Billheimer, J; Rader, DJ; Bachovchin, WW Design and synthesis of boronic acid inhibitors of endothelial lipase. Bioorg Med Chem Lett 22:1397-401 (2012) [PubMed]  Article 
Target
Name:
Endothelial lipase
Synonyms:
EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:
Protein
Mol. Mass.:
56805.62
Organism:
Homo sapiens (Human)
Description:
Q9Y5X9
Residue:
500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
  
Inhibitor
Name:
BDBM50364299
Synonyms:
CHEMBL1952311
Type:
Small organic molecule
Emp. Form.:
C16H19BO3
Mol. Mass.:
270.131
SMILES:
CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1ccoc1
Structure:
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