Reaction Details Report a problem with these data
Target
Transcription factor p65
Ligand
BDBM50365194
Substrate
n/a
Meas. Tech.
ChEMBL_805620 (CHEMBL1955513)
IC50
2650±n/a nM
Citation
 Zuo, Y; Yu, Y; Wang, S; Shao, W; Zhou, B; Lin, L; Luo, Z; Huang, R; Du, J; Bu, X Synthesis and cytotoxicity evaluation of biaryl-based chalcones and their potential in TNFa-induced nuclear factor-¿B activation inhibition. Eur J Med Chem 50:393-404 (2012) [PubMed]  Article 
Target
Name:
Transcription factor p65
Synonyms:
NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1
Type:
Enzyme
Mol. Mass.:
60211.92
Organism:
Homo sapiens (Human)
Description:
Q04206
Residue:
551
Sequence:
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS
  
Inhibitor
Name:
BDBM50365194
Synonyms:
CHEMBL1950372
Type:
Small organic molecule
Emp. Form.:
C25H22FNO4
Mol. Mass.:
419.4449
SMILES:
COc1ccc(\C=C\C(=O)c2ccc(NC(C)=O)c(c2)-c2ccc(F)cc2)cc1OC
Structure:
Search PDB for entries with ligand similarity: