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Target
5-hydroxytryptamine receptor 4
Ligand
BDBM50449570
Substrate
n/a
Meas. Tech.
ChEBML_3325
EC50
3870±n/a nM
Citation
 Flynn, DL; Becker, DP; Spangler, DP; Nosal, R; Gullikson, GW; Moummi, C; Yang, D New aza(nor)adamantanes are agonists at the newly identified serotonin 5-HT4 receptor and antagonists at the 5-HT3 receptor Bioorg Med Chem Lett 2:1613-1618 (1992)    Article 
Target
Name:
5-hydroxytryptamine receptor 4
Synonyms:
5-HT-4 | 5-HT4 | 5-HT4L | 5-HT4S | 5-hydroxytryptamine receptor 4 | 5HT4R_RAT | Htr4 | Serotonin (5-HT) receptor | Serotonin 4 (5-HT4) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46117.31
Organism:
RAT
Description:
5-HT4 HTR4 RAT::Q62758
Residue:
406
Sequence:
MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
  
Inhibitor
Name:
BDBM50449570
Synonyms:
CHEMBL2448137
Type:
Small organic molecule
Emp. Form.:
C16H20ClN3O2
Mol. Mass.:
321.802
SMILES:
COc1cc(N)c(Cl)cc1C(=O)N[C@H]1C2CC3CN(CC13)C2 |r,TLB:12:13:16.15:18.19.21,15:14:19:16.17,THB:17:18:13:16.15,17:16:13:18.19.21,12:13:19:16.17,15:16:19:13.14.21|
Structure:
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