Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50005848
Substrate
n/a
Meas. Tech.
ChEMBL_139646 (CHEMBL748259)
Ki
90±n/a nM
Citation
 Shapiro, G; Floersheim, P; Amstutz, R; Boddeke, H; Bolliger, G; Cottens, S; Enz, A; Gmelin, G; Gull, P; Supavilai, P Muscarinic agonist SAR of azaspirodioxolanes Bioorg Med Chem Lett 2:815-820 (1992)    Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50005848
Synonyms:
(2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,4'-[1,3]dioxolane] | (2'S)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,4'-[1,3]dioxolane] | (2R,2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,4'-[1,3]dioxolane] | 2'-methyl-(2'R)-spiro[4-azabicyclo[2.2.2]octane-2,4'-(dihydro[1,3]dioxolane)] | CHEMBL291280
Type:
Small organic molecule
Emp. Form.:
C10H17NO2
Mol. Mass.:
183.2475
SMILES:
C[C@@H]1OCC2(CN3CCC2CC3)O1 |wD:1.0,(15.15,-4.25,;14.53,-5.65,;15.3,-6.97,;14.28,-8.13,;12.87,-7.51,;12.87,-9.05,;11.53,-9.82,;10.2,-9.05,;10.2,-7.51,;11.53,-6.74,;11,-7.9,;12.13,-8.54,;13.03,-5.97,)|
Structure:
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